Christopher Semsarian Selected Research

Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)

10/2021	Worldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy.
10/2021	Randomized controlled trial of perhexiline on regression of left ventricular hypertrophy in patients with symptomatic hypertrophic cardiomyopathy (RESOLVE-HCM trial).
6/2021	Electrophysiological and Structural Remodeling of the Atria in a Mouse Model of Troponin-I Mutation Linked Hypertrophic Cardiomyopathy: Implications for Atrial Fibrillation.
1/2021	Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation.
1/2021	Myosin Modulation in Hypertrophic Cardiomyopathy and Systolic Heart Failure: Getting Inside the Engine.
1/2021	Evidence-Based Assessment of Genes in Dilated Cardiomyopathy.
1/2021	Clinical Profile and Health Disparities in a Multiethnic Cohort of Patients With Hypertrophic Cardiomyopathy.
10/2020	Clinical Utility of a Phenotype-Enhanced MYH7-Specific Variant Classification Framework in Hypertrophic Cardiomyopathy Genetic Testing.
1/2020	Association of Race With Disease Expression and Clinical Outcomes Among Patients With Hypertrophic Cardiomyopathy.
1/2019	Key Value of RNA Analysis of MYBPC3 Splice-Site Variants in Hypertrophic Cardiomyopathy.

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Christopher Semsarian Research Topics

Disease

39	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 10/2021 - 04/2002
14	Cardiomyopathies (Cardiomyopathy) 03/2022 - 04/2002
14	Sudden Death 10/2020 - 01/2003
13	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2022 - 07/2007
10	Heart Failure 10/2021 - 11/2008
9	Ventricular Tachycardia 01/2021 - 05/2009
8	Heart Diseases (Heart Disease) 04/2022 - 06/2011
8	Cardiac Arrhythmias (Arrythmia) 01/2022 - 12/2005
7	Heart Arrest (Cardiac Arrest) 01/2020 - 07/2007
7	Hypertrophy 01/2016 - 04/2002
6	Cardiomegaly (Heart Hypertrophy) 01/2022 - 09/2003
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 03/2006
5	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 10/2021 - 08/2004
5	Atrial Fibrillation 06/2021 - 07/2014
5	Fibrosis (Cirrhosis) 01/2016 - 04/2008
4	Epilepsy (Aura) 01/2022 - 03/2011
4	Sudden Unexpected Death in Epilepsy 01/2022 - 11/2011
4	Polymorphic catecholergic ventricular tachycardia 01/2020 - 01/2016
3	Channelopathies 01/2022 - 04/2014
3	Shock 01/2022 - 01/2018
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 05/2010
3	Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic) 10/2020 - 10/2006
2	Coronary Disease (Coronary Heart Disease) 01/2022 - 09/2012
2	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 11/2021 - 01/2021
2	Inflammation (Inflammations) 11/2021 - 06/2021
2	Death (Near-Death Experience) 01/2021 - 08/2017
2	Ventricular Fibrillation 01/2021 - 04/2013
2	Sudden Infant Death (SID) 01/2020 - 09/2013
2	Disease Progression 01/2018 - 01/2012
2	Brugada Syndrome 01/2017 - 05/2014
2	Friedreich Ataxia (Friedreich's Ataxia) 09/2013 - 11/2011
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2022
1	Neurodevelopmental Disorders 01/2022
1	Thoracic Aorta Dissection 01/2022
1	Syncope (Fainting) 01/2022
1	Myocarditis (Carditis) 11/2021
1	Ischemic Stroke 01/2021
1	Systolic Heart Failure 01/2021
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2020
1	Stroke (Strokes) 01/2020
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2018
1	Long QT Syndrome 12/2016
1	Bicuspid Aortic Valve Disease 03/2015
1	Cardiac Conduction System Disease 10/2014
1	Pain (Aches) 10/2014
1	Seizures (Absence Seizure) 09/2014

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 11/2021 - 04/2002
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 03/2006
6	Ion Channels (Ion Channel)IBA 12/2016 - 06/2008
5	Troponin IIBA 06/2021 - 02/2005
5	Diltiazem (Cardizem)FDA LinkGeneric 11/2016 - 04/2002
3	myosin-binding protein CIBA 10/2020 - 06/2017
3	RNA (Ribonucleic Acid)IBA 01/2019 - 10/2006
3	DNA (Deoxyribonucleic Acid)IBA 10/2017 - 08/2004
3	CalciumIBA 01/2012 - 01/2006
3	Atrial Natriuretic Factor (ANF)IBA 12/2009 - 10/2006
2	SodiumIBA 01/2022 - 04/2014
2	Voltage-Gated Sodium ChannelsIBA 01/2022 - 10/2014
2	PlakophilinsIBA 10/2021 - 10/2021
2	Ventricular MyosinsIBA 10/2020 - 01/2017
2	LipidsIBA 01/2020 - 12/2009
2	Myosin Heavy Chains (Myosin Heavy Chain)IBA 12/2018 - 06/2017
2	DesminIBA 07/2018 - 05/2010
2	NucleotidesIBA 01/2018 - 04/2014
2	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 01/2016 - 04/2002
2	CalsequestrinIBA 01/2016 - 09/2007
2	FrataxinIBA 09/2013 - 11/2011
2	Connective Tissue Growth FactorIBA 09/2013 - 12/2009
2	Transcription Factors (Transcription Factor)IBA 06/2013 - 06/2011
1	Cytidine Monophosphate (CMP)IBA 03/2022
1	Sodium Channels (Sodium Channel)IBA 01/2022
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2022
1	Lamotrigine (Lamictal)FDA LinkGeneric 01/2022
1	Prostaglandins DIBA 01/2022
1	Illicit Drugs (Recreational Drugs)IBA 01/2022
1	AutoantibodiesIBA 11/2021
1	PerhexilineIBA 10/2021
1	GadoliniumIBA 01/2021
1	Myosins (Myosin)IBA 01/2021
1	Cadherins (E-Cadherin)IBA 01/2021
1	triadinIBA 01/2020
1	Anti-Arrhythmia AgentsIBA 01/2020
1	Epinephrine (Adrenaline)FDA LinkGeneric 01/2019
1	Adenosine Monophosphate (AMP)IBA 01/2018
1	ParaffinIBA 10/2017
1	Formaldehyde (Formol)FDA Link 10/2017
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2017
1	Pharmaceutical PreparationsIBA 01/2017
1	Mitochondrial DNA (mtDNA)IBA 01/2016
1	Cytoskeletal ProteinsIBA 01/2016
1	polyalanineIBA 09/2014

Therapy/Procedure

21	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 04/2022 - 01/2003
16	Therapeutics 01/2022 - 09/2003
7	Defibrillators (Defibrillator) 01/2019 - 07/2007
3	Heart Transplantation (Grafting, Heart) 01/2021 - 07/2014
3	Secondary Prevention 04/2013 - 07/2007
2	Precision Medicine 01/2021 - 01/2021
2	Heart-Assist Devices 10/2020 - 01/2020
1	Electrodes (Electrode) 06/2021
1	Transplantation 08/2017